BIOMG 3800

Advanced Genetics and Genomics

Course Description

Course information provided by the 2026-2027 Catalog.

Why does one mutation lead to a disease state in some individuals but not others? To solve this mystery, we must look beyond single genes and into the interactions between alleles. In this course, students will analyze how systematic mutant collections can reveal essential aspects of eukaryotic biology. Through primary literature, small group discussions, and problem solving, students will integrate classic tools like complementation and genetic mapping with modern strategies like whole genome sequencing and CRISPR-based genome editing to explain the complex relationship between genotype and phenotype.

Prerequisites BIOMG 2800 and BIOMG 2801; or permission of instructor.

Enrollment Information Recommended prerequisites: BIOMG 3300 or equivalent.

Distribution Requirements (OPHLS-AG), (BIO-AS)

Last 4 Terms Offered 2024SP, 2023SP, 2021SP, 2020SP

Learning Outcomes

• Classify the nature and primary effects of mutations, both randomly generated and targeted to recognize the utility of using genetic mutants to study biological mechanisms.
• Identify the biological mechanisms underlying targeted modification of eukaryotic genomes.
• Discriminate the experimental evidence revealing the many ways in which genetic variants interact.
• Discuss the interpretations of genetic interactions, their limitations, and what can be learned by studying these interactions on both a limited and a large scale.
• Explain, evaluate, and effectively interpret claims, theories, and assumptions in the Biological Sciences, including those presented in the scientific literature.
• Formulate and communicate scientific arguments and ideas clearly and explicitly through writing and speech.

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